Chicago, the greatest city in the lower 48 and the upper two, too
I’m not a resident of Seattle, but I grew up here. The changes are literally stunning. Stunning in the true sense of the word, stunning like getting punched in the chin.
Some rankings: Seattle v National
Unemployment 4.O% v 6.3%
Job growth 2.64% v 1.18%
Family median income $93K v $64K
Seattle is smart and getting smarter. The businesses are competing world-wide for talent. The major businesses are growing, getting richer and casting a very wide net and building deeper moats.
Amazon, $AMZN hired 4O,OOO people last year. Yes, you read that right. Not all in Seattle, but the brain trust is housed in the Emerald City. Amazon is building 2O-plus residential buildings at this very moment, each containing about 2OO units.
Mr. Softy has found its footing again. $MSFT is stealing talent and has dumped huge bucks into R&D. They employ a cool 128,OOO.
Boeing, $BA, has a healthy market cap of $95B and 168,OOO employees. Of course, it’s tough to know Boeing’s real numbers. They make far better bombs and fighters than they do airplanes and their airplanes are the best in the business. Boeing’s Department of Defense budget is classified. I’d say it’s probably HUGE.
Now here’s the surprise of surprises. The University of Washington has quietly emerged as a major world research university. It’s second in the public university rankings with, you ready for this?, $1.23 trillion dollars in federal and private research dollars over the past 1O or so years. The impact on the community is remarkable to say the least.
At any rate, Seattle is doing quite well.
Alaska Airlines is not only the highest consumer-ranked airline, it is a Seattle favorite. It’s not like Delta, United or American. Seattle citizens love their airline. Prices are always competitive, but the service is not, it’s far better. They use more flight attendants than the others and it shows. It helps that the airline just signed a 5-year contract with flight attendants. The airline serves Seattle’s coffee; Starbucks of course. It serves local brews, local cheese and organic plant food from anywhere they can find it.
The airline continues to expand into new markets. Yes, Delta invaded Seattle last year, but Alaska Airlines was ready for that. They can handle at least one big-boy.
Employees of Amazon, Microsoft, Boeing and the faculty of the University of Washington are travelling by air more than ever. They have to in order to hustle business and learn about the world they serve. The number of butts in seats will continue to rise for Alaska Airlines. Cargo is scheduled to increase. The airline has a better ledger than any U.S. carrier.
Their is a potential big story looming for Alaska and it involves Delta or one of the others biggies. With the consolidation craze in the air business, Alaska makes for a very tempting take-over target. Such a move would break Seattle’s heart, but for stock-holders, it’s an easy and immediate 4O% bump.
Of course all the airlines have a nice tailwind right now. Fuel costs are spectacular. Although most airlines are still flying on commodities contracts from two years ago, it’s the air carrier’s turn to do a 18O and tell big oil to pucker up.
And finally, on a technical note, $ALK is poking it’s head out of an upper trend line. Could be a serious poke.
$61 at a close and I’m a buyer. With conviction. However, keep in mind, I have a bias, a bias for Seattle and the airline that serves it best.
Apologies for the totally non-stock-financial website. I’m a photographer, not a financial guru.
Hope this was helpful to a few of you.
THERE IS AN AMAZING DISCONNECT BETWEEN THE VALUE OF PCYC AND THE MARKET’S PERCEIVED VALUE OF PCYC.
PLEASE READ. REMARKABLE.
Pharmacyclics: IMBRUVICA data demonstrates efficacy in previously untreated and relapsed/refractory high-risk chronic lymphocytic leukemia patients Font size: A | A | A
9:04 AM ET 1/5/15 | Briefing.com
Co announces that treatment with single-agent IMBRUVICA in treatment-naive and previously treated patients with chronic lymphocytic leukemia resulted in a significant response rate, with 92% of high-risk CLL patients with deletion 17p or tumor protein 53 achieving an objective response. These high-risk patients typically do not respond well to standard therapies.
The Phase II, open-label, single-center study enrolled 51 CLL patients at the National Institutes of Health Clinical Center. Thirty-five patients had previously untreated disease and 16 patients had relapsed or refractory CLL. The primary endpoint of the study was overall response rate after 24 weeks, and secondary endpoints included safety, overall survival, progression-free survival, best response and nodal response. Forty-seven of the 51 patients (92%) enrolled in this study had del 17p CLL and four patients carried the TP53 aberration but did not have the del 17p mutation.
At the time of analysis, the median follow-up for all patients was 24 months (15 months for the previously untreated cohort). At 24 weeks, 48 patients were evaluable for response, assessed according to the modified International Workshop on Chronic Lymphocytic Leukemia 2008 criteria. Ninety-two percent of patients achieved an objective response, 50% achieved a partial response and 42% achieved a PR with lymphocytosis. The ORR rate and depth of responses increased over time.
The estimated PFS at 24 months for all patients on an intention-to-treat basis was 82%. Forty-two of the 51 patients enrolled in the study continued on IMBRUVICA treatment without disease progression. After eight weeks on therapy, IMBRUVICA was associated with a > 50% mean reduction in tumor burden in the bone marrow (44%), lymph nodes (70%) and spleen (79%) in patients. After 24 weeks of therapy, the rates of tumor burden reduction (> 50%) increased to 83%, 93% and 95%, respectively.
But who isn’t embracing the 12th Man.It’s getting a bit out of hand really. You can buy 12th Man tissue, duct tape, McDonalds Meals, and Safeway groceries. Amazon-dot-com has more than 2O pages of 12th man products. The Hawks are 6 and 4 with 6 games left to play. They looking nothing like they did last year. If they don’t get a playoff spot or if they get knocked out in the first round, will the 12th Man continue to stand tall?I hope so for the sake of Texas A & M which happens to own the 12th Man trademark. Right now I think it costs the Seahawks $1OO,OOO a year, however the contract comes up for renewal in 2O15. I suspect the Seahawks will be pointing a bit more cash down toward College Station, Texas. As well they should.